Start by peeling and devening the shrimp if needed. Pat them completely dry with paper towels because excess moisture can prevent the coating from becoming crispy. Dry shrimp also help the coating stick better.
In a shallow bowl, combine the breadcrumbs, grated Parmesan cheese, garlic powder, and Italian seasoning. Stir everything together until the ingredients are evenly distributed. This mixture will create a flavorful crispy exterior.
Place the egg whites or egg substitute into another shallow bowl. The egg mixture acts as a binder and helps the breadcrumb coating adhere to the shrimp during cooking
Dip each shrimp into the egg mixture first. Then coat it thoroughly in the Parmesan breadcrumb mixture, pressing gently so the crumbs stick evenly on all sides.
Preheat your air fryer according to the manufacturer's instructions. A preheated air fryer helps the shrimp start crisping immediately and promotes even cooking.
Lightly spray the air fryer basket with nonstick cooking spray. Arrange the coated shrimp in a single layer, leaving space between each piece so the hot air can circulate properly.
Cook the shrimp at 400°F (200°C) for about 8 to 10 minutes. Halfway through cooking, carefully flip the shrimp to ensure both sides become golden brown and crispy.
The shrimp should be opaque and firm when fully cooked. Avoid overcooking because shrimp can become rubbery very quickly once they pass the ideal cooking point.
Transfer the cooked shrimp to a serving platter. Garnish with chopped parsley and serve with fresh lemon wedges for an extra burst of flavor.