Creamy Buffalo Chicken Lasagna Roll Ups Recipe: Cheesy & Comforting Dish

When I first made these Creamy Buffalo Chicken Lasagna Roll Ups, I wasn’t expecting them to taste this good. The creamy Alfredo sauce mixed with spicy buffalo heat turned out to be a match made in heaven.

Each roll felt like comfort food wrapped up in a little cheesy package. I served them to my family, and everyone went back for seconds without hesitation. Honestly, this is one of those recipes I’ll be making again and again!

Creamy Buffalo Chicken Lasagna Roll Ups Recipe

Ingredients for Creamy Buffalo Chicken Lasagna Roll Ups

Here’s everything you’ll need to bring these roll ups to life, along with a few tips I’ve learned while making them.

12 lasagna noodles – Cook until al dente so they roll without tearing.
3 cups shredded rotisserie chicken – Rotisserie chicken adds flavor and saves prep time.
8 ounces cream cheese, softened – Brings that rich, creamy texture to the filling.
2 cups shredded mozzarella cheese – Use freshly grated mozzarella for the best melt.
1 teaspoon garlic powder – Adds depth and balances the tangy buffalo flavor.
½ teaspoon onion powder – Subtle flavor that complements the creamy filling.
1 tablespoon chopped chives – Freshness that cuts through the richness.
½ teaspoon salt – Enhances all the other flavors.
1½ cups Alfredo sauce – A smooth, creamy base for the buffalo sauce.
½ cup Louisiana hot sauce – Brings the signature spicy kick.

Note: This recipe makes about six servings. Perfect for a family dinner or to share with friends!

Variations to Try

One of the best parts about this recipe is how easily it adapts to different tastes.

Swap the chicken for turkey, pulled pork, or even ground beef.
Use Monterey Jack or pepper jack cheese if you want extra flavor.
Try barbecue or a mango habanero sauce instead of buffalo sauce for a twist.
For a low-carb version, replace the lasagna noodles with zucchini strips.

Cooking Time

Here’s the time breakdown so you know exactly what to expect:

Prep Time: 25 minutes
Cooking Time: 30 minutes
Total Time: 55 minutes

Equipment You’ll Need

Having the right tools makes this recipe easier.

Large pot – To boil the lasagna noodles.
Mixing bowls – For preparing the filling and sauces.
Baking dish – To assemble and bake the roll ups.
Foil – Keeps the dish moist during the first part of baking.

How to Make Creamy Buffalo Chicken Lasagna Roll Ups?

Let’s walk through the steps together — once you make it this way, you’ll never forget!

Cook and Cool the Noodles

Start by boiling the noodles in salted water until al dente, about 8–10 minutes. Drain and lay them flat on parchment paper to prevent sticking and tearing. This step makes rolling much easier later.

Make the Chicken Filling

In a bowl, mix shredded chicken with cream cheese, half the mozzarella, garlic powder, onion powder, chives, and salt. Stir until the mixture is creamy and smooth. This filling is the heart of your roll ups.

Mix the Buffalo Alfredo Sauce

In another bowl, whisk together Alfredo sauce and hot sauce until fully blended. This is where the bold flavor comes from. The creaminess and heat balance each other beautifully.

Assemble the Roll Ups

Spread a thin layer of buffalo Alfredo sauce in your baking dish. Lay out each noodle, spread filling evenly, then roll it up tightly. Place them seam-side down in the dish, side by side.

Top with Sauce and Cheese

Pour the rest of the buffalo Alfredo sauce over the roll ups. Sprinkle with the remaining mozzarella for a gooey, golden topping that everyone will love.

Bake to Perfection

Cover the dish with foil and bake at 375°F for 20 minutes. Remove the foil and bake another 10 minutes until the cheese is bubbly and slightly browned. Garnish with extra chives before serving.

Additional Tips for Making this Recipe Better

After making this a few times, here’s what worked best for me:

I slightly undercook the noodles so they don’t fall apart when rolling.
I always spread plenty of sauce on top — it keeps the roll ups moist and flavorful.
Making homemade Alfredo sauce when I have time really lifts the flavor.
If serving kids, I cut down on the buffalo sauce for a milder version.

How to Serve Creamy Buffalo Chicken Lasagna Roll Ups?

These roll ups work well as both a family dinner and a party dish. For a cozy meal, I like to serve them with garlic bread and a crisp salad. At potlucks, I slice them into smaller portions and add extra buffalo sauce or ranch on the side. Roasted veggies are another great partner if you want a lighter balance.

Nutritional Information

Here’s a quick look at what you’ll get per serving:

Calories: 987
Protein: 113g
Carbohydrates: 47g
Fat: 39g

Make Ahead and Storage

Make Ahead

I usually prep the roll ups a day or two before baking. Just cover the dish tightly with plastic wrap and refrigerate. Add 5–10 extra minutes to the bake time if starting from chilled.

Storage

Leftovers keep well in the fridge for 2–3 days in an airtight container. Reheat at 350°F in the oven to keep the cheese gooey.

Freezing

These also freeze beautifully! Store them in a freezer-safe dish for up to 3 months. Thaw overnight in the fridge before baking.

Why You’ll Love This Recipe

There are so many reasons this recipe has become one of my favorites:

It’s packed with flavor — creamy, spicy, and cheesy all at once.
It saves time since rotisserie chicken makes prep so quick.
It looks fancy enough for guests but is simple to make.
It’s customizable, so you can adjust spice or swap ingredients.
It works perfectly for meal prep, making weeknights stress-free.

Ash Tyrrell